Protein Details: Neuronal acetylcholine receptor subunit beta-3

Protein ID

ICDB_Pro_0532

Protein Name

Neuronal acetylcholine receptor subunit beta-3

Gene Name

CHRNB3

Organism

Gallus gallus (Chicken)

Length

455 amino acids

AlphaFoldDB

AF-P43679-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

MLCLMLCVLCWSRSDVAALGSVVENEDALLRHLFQGYQKWVRPVENSNDTIKVLFGLKISQLVDVDEKNQLMTTNVWLKQEWMDHKLSWNPEEYGGITAIRVPSESLWLPDIVLFENADGRFEGSLMTKAIVKYNGVVQWMPPASYKSSCTMELTFFPFDRQNCSMKFGSWTYDGSMVDLILVDENVDTKDFFDNGEWEILNAKGMKGNRKDGLYSYPFVTYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHPMAPWVKRLFLQKLPRLLCMKGHVDRYSFSDTEEKETTLKSKLPGKQKHKQAKDGEKVVIAFLEKAADSIRYISRHVKKDAFIRQVVQDWKFVAQVLDRIFLWLFLVVSVTGSVLIFTPALQMWLNSTL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 114: "Key residue for a low dissociation (K(off)) from the conotoxin BuIA"

Disease

Location

DOI ID

10.1016/s0021-9258(18)38201-2